Anna Mapp ’92 Wins Award for Study of Proteins

Posted February 12th, 2015 at 12:28 pm.

AnnaMappAnna Mapp ’92 is the most recent recipient of the 2015 The Emil Thomas Kaiser Award, given by the Protein Society. This award recognizes a recent, highly significant contribution in applying chemistry to the study of proteins.

Mapp, a professor of chemistry at the University of Michigan, uses innovative chemical biology in which insight into protein-protein interactions is used to inspire the design, synthesis, and screening of small molecules that can then be used to modulate those interactions to provide molecular-level insight into how genes are regulated at the transcriptional level. Her work has captured the molecular detail of transcriptional activators interacting with the transcriptional machinery in vivo, defining the resulting complexes kinetically and thermodynamically, work that is regarded as a landmark accomplishment. Small molecules developed in her pioneering work are deployed not only as mechanistic probes, but also as first-generation, transcription-targeted therapeutics. Her research provides an example of successful scientific reductionism—distilling a complex biological problem into the realm of chemistry.

Filed under: 1990s,awards,Chemistry,sciences Tags: , by Diana Campeggio

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